A unique option which Duranglers will gladly fill you in on is to take this:
the Durango & Silverton Train up through this:
and get off the train here:
in the middle of the wilderness with no roads and fish this:
for a while and then catch the train on its way back from Silverton. Some camp for a day or so before catching the train back. There are small streams you can fish up also.
The wife can stay on the train to Silverton and shop.
The train ride is gorgeous but I have not gotten off to fish the Animas myself. You will be catching average size fish of 10 - 14 inches but the setting is worth it. Mostly browns I believe.